• Joint PhD student between University of Lille and Ghent University

3D-printed scaffolds for cancer treatment


Proposal Call: Joint PhD student between University of Lille and Ghent University

Job description

The current PhD project covers the interdisciplinary fields of chemistry, materials science, engineering and cell biology to develop 3D-printed scaffolds for cancer treatment. More specifically, crosslinkable polymers will be applied as starting materials for 3D-printing. The selected materials will be based on proteoglycans and saccharide functionalization to attract circulating cancer cells (CTCs). The scaffold core will contain cyclodextrins which house chemotherapy (e.g. paclitaxel) to be released in the presence of cancer cells. The main focus of the proposed PhD research will be on polymer synthesis and 3D-printing.

The project involves the following research groups:

Prof. Philippe Zinck (UCCS – Unité de Catalyse et Chimie du Solide, Université de Lille, Campus Cité scientifique, Villeneuve d’Ascq, France)

Prof. Sandra Van Vlierberghe (Polymer Chemistry & Biomaterials Group, Ghent University, Krijgslaan 281, S4-Bis, 9000 Ghent, Belgium)

Dr. Elly De Vlieghere (Laboratory of Experimental Cancer Research, Ghent University, Belgium)

Relevant literature to consult:

      Miao et al., Access to new carbohydrate-functionalized polylactides via organocatalyzed ringopening polymerization, Polymer 52 (2011) 5018-5026

      De Vlieghere et al., Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells, Biomaterials 54 (2015) 148-157

      Houben et al., Flexible oligomer spacers as the key to solid-state photopolymerization of hydrogel precursors, Materials Today Chemistry 4 (2017) 84-89

Profile of the candidate

Candidates should have a master’s degree before 07/2019. Candidates with a degree in chemistry and an interest in health science of a degree in health science and an interest in chemistry are encouraged to apply.

In case of interest, please contact before 19th April 2019: